Friday, May 31, 2019

What is Knockout Animals and Purpose do They Serve?

Knockout mice, credit to National Human Genome Research Institute.
Knockout is insertion of modified DNA at a specific homologous site in the animal genome. It is interesting to discuss about knockout term furthermore in this term paper.
In addition, knockout is the word commonly used to inactive an exist of specific gene in particular organism.
The way to knocked out is by replacing or disrupting the target gene with an artificial piece of DNA.
This is a genetic technique by using homologous recombination to change an endogenous gene. Then, targeted gene could be permanent or conditional inactive or knockout.
Knockout could cause alter phenotype of organisms. The changes might include behavior, appearance (observable physical) and biochemical characteristics of organisms.
Then, knockout organisms are used in learning about a gene that has been sequenced, which incompletely known function.
North Carolina Association for Biomedical Research (2016) reported that knockout technique by inactivated specific gene is one example of using biotechnologies in modern era.
Inactivated specific genes is the biochemical and pathological basis that might be used to understand human diseases. For these purposes the scientists produced a knockout mouse.
NIH (2015) informed that human share many genes with mice. Thus, observing knockout mice gives information that can be used to better understand how a similar gene may cause or contribute to disease in humans.
So far, knockout mice have been used to understand many diseases, including cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson disease.

References
NIH (National Human Genome Research Institute). 2015. Knockout Mice.
Retrieved from https://www.genome.gov/12514551/
North Carolina Association for Biomedical Research. 2016. Animal
Biotechnology. Retrieved from http://www.aboutbioscience.org/topics/animalbiotechnology

84 comments:

  1. Replies
    1. Thank you for stopping by
      What is Knockout Animals and Purpose do They Serve?
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      Knockout mice, credit to National Human Genome Research Institute.

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  2. That sounds very interesting!! Fantastic post!

    Kisses :)

    ReplyDelete
  3. Hi! Interesting post. Thanks for sharing.
    Have a nice day!

    ReplyDelete
  4. nice post, thanks for sharing

    www.torichux3.com

    ReplyDelete
    Replies
    1. Thank you for stopping by
      @

      What is Knockout Animals and Purpose do They Serve?

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  5. Great info that encourages me to investigate more about this interesting topic. I already knew that we were in debt to mice and other creatures ...

    Big hug, Evi.

    ReplyDelete
  6. Replies
    1. Your welcome :)
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      North Carolina Association for Biomedical Research (2016) reported that knockout technique by inactivated specific gene is one example of using biotechnologies in modern era.

      Delete
  7. Matéria é que
    informa e alerta.
    Grata.
    Bjins
    CatiahoAlc.

    ReplyDelete
    Replies
    1. Thank you
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      Inactivated specific genes is the biochemical and pathological basis that might be used to understand human diseases. For these purposes the scientists produced a knockout mouse.

      Delete
  8. Very interesting topic.
    Kisses!

    galerafashion.com

    ReplyDelete
    Replies
    1. Thank you
      -
      So far, knockout mice have been used to understand many diseases, including cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson disease.

      Delete
  9. Replies
    1. Thank you
      -
      This is a genetic technique by using homologous recombination to change an endogenous gene. Then, targeted gene could be permanent or conditional inactive or knockout.

      Delete
  10. Pobres ratoncitos , aunque sufren por un buen propósito. Te mando un beso

    ReplyDelete
    Replies
    1. Thank you
      -
      Knockout is insertion of modified DNA at a specific homologous site in the animal genome. It is interesting to discuss about knockout term furthermore in this term paper.

      Delete
  11. Luar biasa ya kuasa Tuhan .., melalui kecerdasan ilmuwan bermacam jenus penyakit dapat terdeteksi melalui uji coba badan hewan.

    Informasi menarik

    ReplyDelete
    Replies
    1. Thank you
      -
      In addition, knockout is the word commonly used to inactive an exist of specific gene in particular organism

      Delete
  12. To bardzo interesujące zagadnienie, jest nadzieja na pomoc dla wielu chorych.
    Miłej niedzieli Evi!

    ReplyDelete
    Replies
    1. Thank you Ewa
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      The way to knocked out is by replacing or disrupting the target gene with an artificial piece of DNA.

      Delete
  13. Replies
    1. Thank you
      -
      Inactivated specific genes is the biochemical and pathological basis that might be used to understand human diseases. For these purposes the scientists produced a knockout mouse.

      Delete
  14. It is amazing what they discover in research!

    ReplyDelete
  15. Wah baru tau saya tikus knockout banyak memberikan informasi ttg penyakit manusia

    ReplyDelete
  16. Olá! Boa Bom dia!!

    Neste mundo virtual encontramos de tudo, mas o seu blog é maravilhoso, vale a pena seguir e já estou ficando, com certeza voltarei mais vezes.
    Criamos um blog para nossa escola- RAIMUNDO HONÓRIO, recém-nascido, mas será um prazer ter você seguindo e nos impulsionando com este trabalho virtual que estamos organizando no nosso cantinho que também é de todos!
    Tenha um fim de semana feliz e abençoado. Abraços da família RH.

    ReplyDelete
    Replies
    1. Thank you
      -
      So far, knockout mice have been used to understand many diseases, including cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson disease.

      Delete
  17. Very educational post, you always write something interesting

    ReplyDelete
    Replies
    1. Thank you
      -
      Knockout is insertion of modified DNA at a specific homologous site in the animal genome. It is interesting to discuss about knockout term furthermore in this term paper.

      Delete
  18. Vim agradecer sua visita e por seguir nosso blog. Seja bem vinda! Abraços da família RH.

    ReplyDelete
    Replies
    1. Thank you
      -
      This is a genetic technique by using homologous recombination to change an endogenous gene. Then, targeted gene could be permanent or conditional inactive or knockout.

      Delete
  19. Replies
    1. Thank you
      -
      North Carolina Association for Biomedical Research (2016) reported that knockout technique by inactivated specific gene is one example of using biotechnologies in modern era.

      Delete
  20. so, any types of mice? or only selected mice?

    ReplyDelete
  21. I hope that we can find another system to do it and not use animals.

    ReplyDelete
  22. Interesting topic and research. Have a good week!

    ReplyDelete
  23. Articolo davvero interessante..grazie delle informazioni

    https://nettaredimiele.blogspot.com

    ReplyDelete
  24. Very interesting info, thanks for sharing!
    xx

    ReplyDelete
  25. Saya mengucapkan selamat berpuasa dan selamat hari raya idulfitri.

    MOHON MAAF LAHIR DAN BATIN

    kepada semua taman taman blogger muslim dan muslimat disini..🙏🙏🙏

    ReplyDelete
  26. My disease is also a malformation of a gene !! This is a very important technique !!
    xoxo

    marisasclosetblog.com

    ReplyDelete
    Replies
    1. I agree, this finding is very important

      Thanks Marisa

      Delete
  27. Very interesting post.

    www.paginasempreto.blogspot.com.br

    ReplyDelete
  28. Very interesting post. Thanks for sharing!

    ReplyDelete
  29. Las ciencias,y no las religiones son motores para la nuestra evolución

    ReplyDelete
  30. Bardzo ciekawe zagadnienie :)

    ReplyDelete
  31. Hai! Posting menarik. Terima kasih telah berbagi.
    Semoga harimu menyenangkan!

    ReplyDelete
  32. Saya berharap kita dapat menemukan sistem lain untuk melakukannya dan tidak menggunakan hewan.

    ReplyDelete
  33. Hello Evi-Erlinda!
    You leave us a very important text about
    Research to understand human diseases. It seems a lie, but it is true that mice share genes with us and can effectively contribute to fight important diseases in humans.
    This reading has been a pleasure, thank you.
    I leave you my immense gratitude for your coal in my space.

    A kiss and I am very, very happy

    ReplyDelete
  34. ¡Hola Evi-Erlinda!
    Nos dejas un muy importante texto sobre
    Investigación para comprender las enfermedades humanas. Parece mentira, pero es verdad que los ratones comparten genes de nosotros y efectivamente pueden contribuir y así poder combatir importantes enfermedades en los seres humanos.

    Ha sido un placer esta lectura, gracias.
    Te dejo mi inmensa gratitud por tu hulla en mi espacio.
    Un beso y se muy, muy feliz

    ReplyDelete
  35. Estupenda entrada! gracias por tu visita! feliz dia!!! :-) :-) :-)

    ReplyDelete
  36. mice are top 10 animals used for experiments

    ReplyDelete
  37. I hear something about it for the first time
    greetings
    Lili

    ReplyDelete
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