Sunday, June 30, 2019

How Early a Person was Diagnosed to Get Alzheimer’s Diseases? - Alzheimer's #2.

Dr. Alois Alzheimer, a German neurologist
(Picture: US National Library of Medicine)
It's over than one century since a German physician and psychiatrist, Alois Alzheimer, observed his patient with suffered loss of memory and language. She (his patient) also had hallucinations, delusions, and cognitive impairment.
She was only 51 year-old and too early to had a dementia, so she was diagnosed as presenile dementia. 
Dr. Alzheimer identified and described her psychological and behavioral, then when she passed away, Dr Alzheimer asked her family to autopsy her brain. 
He took her brain tissue to laboratory and did staining to get observation in her nervous system. Fortunately, at that time the research methods using stain was developed. 
The staining was able to visualize the nerve cells. 
He found “dramatic brain shrinkage and abnormal deposits in and around nerve cells” and the abnormal deposit in today are called amyloid plaques and neurofibrillary tangles.


Histopathology of Alzheimer's diseases 
(Picture from Neuroscience, Purves, et al)
From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem. 
The causes of Alzheimer's Disease is not fully understand yet. 
There are three principle features could be detected in every person who severe with the Alzheimer's disease:
  1. Collection of intra-neuronal cytoskeletal filaments or neurofibrillary tangles, also known as aggregate tau protein in the brain.
  2. Extracellular deposit of an abnormal amyloid or amyloid plaques.
  3. A diffuse loss of neurons. The accumulation of neurofibrillary tangles and amyloid plaques lead to death of neuron cells so that the brain became shrinkage. 

72 comments:

  1. menarik mba Ev, dulu aku belajar psikologi dan memang diajari pula fisiologi juga anatomi otak begitu..dan ternyata ada penyusutan yah ngeri juga :(

    ReplyDelete
    Replies
    1. Thanks Herva
      ^-^
      Dr. Alzheimer identified and described her psychological and behavioral, then when she passed away, Dr Alzheimer asked her family to autopsy her brain.

      Delete
    2. i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
      or
      call/whatsapp:+2349057261346

      Delete
  2. ulasannya memberikan pemahaman tentang penyakit yang diderita oleh petinju legendaris Moh.Ali. terima kasih

    ReplyDelete
    Replies
    1. Thank you
      ^-^
      From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem.

      Delete
  3. Detailed report, Evi, about a painful issue that increasingly affects more people. Let science find methods and treatment to contain and give quality of life to those who suffer or will suffer, since it is a seemingly invincible disease, from the point of view that all without exception we will grow old.

    Thanks again, Evi. Hugs.

    ReplyDelete
    Replies
    1. Thank you
      Hugs!
      -
      She was only 51 year-old and too early to had a dementia, so she was diagnosed as presenile dementia.

      Delete
  4. So interesting post :) I'm very into this subject.

    ReplyDelete
    Replies
    1. Thanks Sabina
      ^-^
      She was only 51 year-old and too early to had a dementia, so she was diagnosed as presenile dementia.

      Delete
  5. Muy interesante esta entrada.

    #Besos N.

    ReplyDelete
    Replies
    1. Thank you
      ^_^

      From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem.

      Delete
  6. Replies
    1. Thank you
      ^-^
      Dr. Alzheimer identified and described her psychological and behavioral, then when she passed away, Dr Alzheimer asked her family to autopsy her brain.

      Delete
  7. Replies
    1. Thanks :)
      @
      He took her brain tissue to laboratory and did staining to get observation in her nervous system. Fortunately, at that time the research methods using stain was developed.

      Delete
  8. Replies
    1. Thank you Erra
      ^_^

      From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem.

      Delete
  9. Very informative post. It is a dreadful disease.

    ReplyDelete
    Replies
    1. Thank you Nancy
      ^-^
      He took her brain tissue to laboratory and did staining to get observation in her nervous system. Fortunately, at that time the research methods using stain was developed.

      Delete
  10. Muy interesante la información que nos detallas. Un beso y feliz semana

    ReplyDelete
    Replies
    1. Thank you
      -
      Dr. Alzheimer identified and described her psychological and behavioral, then when she passed away, Dr Alzheimer asked her family to autopsy her brain.

      Delete
  11. Very interesting, you know a lot in this topic:)

    ReplyDelete
    Replies
    1. Thank you
      -
      From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem.

      Delete
  12. Replies
    1. Thank you
      -
      He took her brain tissue to laboratory and did staining to get observation in her nervous system. Fortunately, at that time the research methods using stain was developed.

      Delete
  13. thank you so much for wonderful blog and useful sharing my friend!

    i am so much interested in human brain since always , i think it is biggest carnation of nature

    most wonderful and amazing thing yet so complicated to understand fully
    so glad to find you here

    ReplyDelete
  14. I was always fascinated by how the doctor was sure for what to look. He must have been really smart to figure it out.

    ReplyDelete
  15. My disease is caused too by the accumullation of amyloid protein in the body, I have Paramiloidosis it'a a rare disease. I did not know that about Alzheimer disease.
    xoxo

    marisasclosetblog.com

    ReplyDelete
    Replies
    1. Thank you
      ^-^
      From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem.

      Delete
  16. Replies
    1. Thank you
      ^_^

      From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem.

      Delete
  17. Very interesting post.

    www.paginasempreto.blogspot.com.br

    ReplyDelete
    Replies
    1. Thank you
      -
      He found “dramatic brain shrinkage and abnormal deposits in and around nerve cells” and the abnormal deposit in today are called amyloid plaques and neurofibrillary tangles.

      Delete
  18. Really interesting information about a terrible disease.

    www.jessicabroyles.com

    ReplyDelete
    Replies
    1. Thank you
      -
      If above activities need looking down to mobile phone too long, it would cause what experts call as “tech neck.”

      Delete
  19. Wow this is so interesting. I didn´t knew about this
    xx

    ReplyDelete
  20. Ah yes I learned quite a bit about Alzheimers as last year I worked for a publisher and designed an entire magazine on this topic. You may still find it in Whole Foods. It was eye opening for sure.

    Allie of
    www.allienyc.com

    ReplyDelete
  21. Replies
    1. Thank you
      -
      From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem.

      Delete
  22. It is a dreadful and most cruel disease.
    Interesting to read your post.

    Many are beginning to think that a diet lower in carbohydrates and higher in healthy fats may help and be beneficial. There are quite a few articles about this on the internet.

    All the best Jan

    ReplyDelete
  23. Very informative.
    It's a dreadful disease.

    galerafashion.com

    ReplyDelete
    Replies
    1. Thank you
      -
      He found “dramatic brain shrinkage and abnormal deposits in and around nerve cells” and the abnormal deposit in today are called amyloid plaques and neurofibrillary tangles.

      Delete
  24. Thank you for a lot of important information !
    Greetings

    ReplyDelete
  25. La ciencia nos alargar la vida,pero las enfermedades nos castigan

    ReplyDelete
  26. Very interesting information, I didn't know about it!
    xx

    ReplyDelete
    Replies
    1. Thank you
      ^_^

      From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem.

      Delete
  27. I learned a quite a lot about alzheimer disease when during some of my psychology classes while in college. This is a very interesting post.

    ReplyDelete
  28. Muy interesante y no lo sabía aunque también me da mucha pena esa enfermedad. Te mando un beso

    ReplyDelete
  29. awesome article.
    thanks for sharing :)

    ReplyDelete
  30. Muy interesante. Ojala se encontrara cura para esta enfermedad, saludos amiga.

    ReplyDelete
    Replies
    1. Thank you
      -
      From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem.

      Delete
  31. Replies
    1. Thanks Joanna
      @
      Dr. Alzheimer identified and described her psychological and behavioral, then when she passed away, Dr Alzheimer asked her family to autopsy her brain.

      Delete
  32. Very interesting post! It is very important to know about alzheimer.Someone who has got alzheimer has got harder and more difficult life than other people :(. Amazing blog! I will come back soon :)). Big hugs!

    ReplyDelete
    Replies
    1. Thank you
      -
      From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem.

      Delete
  33. Interesting post. This disease is awful

    ReplyDelete
  34. I know a few people whose parents/grandparents have this. I wish Alzheimer and dementia can be cured:(

    ReplyDelete
    Replies
    1. I hope so, thanks Emmylou :)
      @
      Dr. Alzheimer identified and described her psychological and behavioral, then when she passed away, Dr Alzheimer asked her family to autopsy her brain.

      Delete
  35. Today my knowledge improves by reading this article. So the photo above was Dr. Alois Alzheimer

    ReplyDelete
    Replies
    1. Thanks Aries
      ^-^
      It's over than one century since a German physician and psychiatrist, Alois Alzheimer, observed his patient with suffered loss of memory and language. She (his patient) also had hallucinations, delusions, and cognitive impairment.

      Delete
  36. I like read your post. It is very important to know about Alzheimer.
    Kiss

    ReplyDelete
  37. A great review indeed, thanks for sharing!

    ReplyDelete
  38. Gosto imenso das informações que partilhas
    Interessantíssimo esse texto.
    Beijinhos

    ReplyDelete
    Replies
    1. Thank you Gracita
      -
      From the picture, the yellow colors are neurofibrillary tangles, and brown darks are amyloid plaques. Specifically, they are in the neocortex, amygdala, and brainstem.

      Delete
  39. i think 51 years old not too old to had a dementia.
    Is she a hardcore smoker before getting this disease?

    ReplyDelete
  40. i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
    or
    call/whatsapp:+2349057261346

    ReplyDelete

Why Persian Cats Have Long Silky Fur?

The Persian cat Persian cat is popular and even most popular cat in the America in recent years. It got attention by households as ...