Tuesday, July 2, 2019

How did Dr. Alzheimer find out the changes in his patient's brain? - Alzheimer's #3.

Nissl-stained in the brain tissue 
(Picture from Neuroscience, Purves, et al)

As we know Alzheimer's Disease is a kind of dementia that has specific signs and symptoms.
Based on clinical research a patient who has dementia with Alzheimer's Disease has accumulation of neurofibrillary tangles and amyloid plaques in the brain.
This disease got the name after a Germany physician and clinical psychiatrist, and also conducted some research related to brain disorders, Dr Alois Alzheimer.
Dr. Alzheimer was excited about working in the laboratory. Franz Nissl who discovered a special staining technique became his coworker and then also taught him about staining. 
At that time, the staining in the lab helped the scientists to discover new finding in the organelles of the human body. 
He worked with Nissl for couple years before Nissl moved out for better facility in his research. But they kept in touch being the best friend forever.


Example photo brain tissue by using fluorescence staining
(Picture from sciencephoto.com)

Nissl discovered what we known as Endoplasmic Reticulum. In the past this organelle also called Nissl body. 

In the lab that coordinated by Dr. Alzheimer, some sources mention about Alzheimer team, including H.G Crcutzfeld and A. Jakob. 

Based on H. G Creutzfeld and A. Jakob finding, we got an understanding about mad cow that also called Creutzfeldt-Jakob Disease (CJD). 

The disease caused by eating bad meat or the meat from the cattle that infected by a certain disease.

Another brilliant person who had been worked in the same lab was Frederic Henry Lewy. He discovered the abnormal accumulation of protein (Lewy bodies). Then we known as Lewy body dementia.
Lewy body dementia (LBD) is a kind of dementia which associated with abnormal deposits of a protein (alpha-synuclein) in the brain.  

The common clinical manisfestations of Lewy body dementia are disturbance in thinking, memory, and movement (motor control). It is the second most common type of progressive dementia after Alzheimer's disease. 


So Dr. Alzheimer found the changes of brain features of his patient by staining the tissue of his patient's brain.

64 comments:

  1. Replies
    1. Thank you Anies

      @

      Based on clinical research a patient who has dementia with Alzheimer's Disease has accumulation of neurofibrillary tangles and amyloid plaques in the brain.

      Delete
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      Delete
    3. Dear>
      Appreciate....
      How did Dr. Alzheimer find out the changes in his patient's brain? - Alzheimer's #3.

      Nissl-stained in the brain tissue
      (Picture from Neuroscience, Purves, et al)

      Delete
    4. Landy>
      Appreciate....
      How did Dr. Alzheimer find out the changes in his patient's brain? - Alzheimer's #3.

      As we know Alzheimer's Disease is a kind of dementia that has specific signs and symptoms.

      Delete
  2. muy interesante, gran investigación. Te mando un beso

    ReplyDelete
    Replies
    1. Thank you
      @
      Lewy body dementia (LBD) is a kind of dementia which associated with abnormal deposits of a protein (alpha-synuclein) in the brain.

      Delete
    2. Appreciate....
      How did Dr. Alzheimer find out the changes in his patient's brain? - Alzheimer's #3.
      -
      Based on clinical research a patient who has dementia with Alzheimer's Disease has accumulation of neurofibrillary tangles and amyloid plaques in the brain.

      Delete
  3. awesome article..
    thanks for sharing :)

    ReplyDelete
    Replies
    1. Appreciate....
      How did Dr. Alzheimer find out the changes in his patient's brain? - Alzheimer's #3.
      -
      This disease got the name after a Germany physician and clinical psychiatrist, and also conducted some research related to brain disorders, Dr Alois Alzheimer.

      Delete
  4. Very interesting info. It is complemented with previous entry. Thank you very much, Evi.

    Hugs.

    ReplyDelete
    Replies
    1. Appreciate.
      How did Dr. Alzheimer find out the changes in his patient's brain? - Alzheimer's #3.
      -
      Dr. Alzheimer was excited about working in the laboratory. Franz Nissl who discovered a special staining technique became his coworker and then also taught him about staining.
      -


      Delete
  5. Interesting post. Have a beautiful day :)
    I'm your new follower :)

    ReplyDelete
  6. Tengo un familiar con esa enfermedad. Es interesante lo que compartes. Saludos amiga.

    ReplyDelete
    Replies
    1. Thank you Sandra
      @
      Dr. Alzheimer found the changes of brain features of his patient by staining the tissue of his patient's brain.

      Delete
  7. Replies
    1. Thank you Sunika
      @
      Based on H. G Creutzfeld and A. Jakob finding, we got an understanding about mad cow that also called Creutzfeldt-Jakob Disease (CJD).

      Delete
  8. Very interesting. Hope more research will be done to help those with this disease.

    ReplyDelete
    Replies
    1. Thank you Nancy
      @
      Based on clinical research a patient who has dementia with Alzheimer's Disease has accumulation of neurofibrillary tangles and amyloid plaques in the brain.

      Delete
  9. Very interesting post. Thanks for sharing.

    Best regards

    ReplyDelete
    Replies
    1. Thank you
      @
      Dr. Alzheimer was excited about working in the laboratory. Franz Nissl who discovered a special staining technique became his coworker and then also taught him about staining.

      Delete
  10. Replies
    1. Thank you
      @
      This disease got the name after a Germany physician and clinical psychiatrist, and also conducted some research related to brain disorders, Dr Alois Alzheimer.

      Delete
  11. I tuoi articoli sono sempre così interessanti, utili e molto chiari.
    Un bacio dall'Italia

    https://nettaredimiele.blogspot.com

    ReplyDelete
    Replies
    1. Thanks
      @
      Based on clinical research a patient who has dementia with Alzheimer's Disease has accumulation of neurofibrillary tangles and amyloid plaques in the brain.

      Delete
  12. It is so important to keep learning of this disease.

    ReplyDelete
  13. Interesting, thanks you for this information

    ReplyDelete
    Replies
    1. Thank you
      @
      At that time, the staining in the lab helped the scientists to discover new finding in the organelles of the human body.

      Delete
  14. I knew he made an autopsy and examined the patient's brain (thus finding the illness) but I didn't know about the details and about other scientists who worked on similar projects.

    ReplyDelete
    Replies
    1. Thank you
      @
      In the lab that coordinated by Dr. Alzheimer, some sources mention about Alzheimer team, including H.G Crcutzfeld and A. Jakob.

      Delete
  15. Thanks a lot :D

    have a nice day, my friend

    NEW FASHION POST | HOW TO USE BRALETTE!! :O
    InstagramFacebook Official PageMiguel Gouveia / Blog Pieces Of Me :D

    ReplyDelete
  16. This terrible disease!
    Some people call it "hell on earth"!
    Thanks for visiting!

    Best regards!

    ReplyDelete
  17. Despite being such a sad disease, they are beautiful images. Have a great day!

    Blog Paisagem de Janela
    www.paisagemdejanela.com

    ReplyDelete
    Replies
    1. Thank you
      @
      The disease caused by eating bad meat or the meat from the cattle that infected by a certain disease.

      Delete
  18. I was thinking that LBD was little black dress ahhahah!!!
    The pics are stunning!!
    xoox

    marisasclosetblog.com

    ReplyDelete
  19. İmportant informations. Thank you for sharing. I followed you.

    ReplyDelete
    Replies
    1. Thank you
      @
      Dr. Alzheimer was excited about working in the laboratory. Franz Nissl who discovered a special staining technique became his coworker and then also taught him about staining.

      Delete
  20. Interesting post my dear, thank you for sharing.

    ReplyDelete
    Replies
    1. Thank you
      @
      This disease got the name after a Germany physician and clinical psychiatrist, and also conducted some research related to brain disorders, Dr Alois Alzheimer.

      Delete
  21. That was a stellar cast of researchers in that lab.

    ReplyDelete
  22. Knowing all the histological aspect of this disease is quite interesting.

    ReplyDelete
  23. Hi,
    You have an amazing blog. Do you want to follow each other?

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  24. Tu blog nos manda mucha cultura,te estamos agradecido por ello.

    ReplyDelete
  25. Very informative. I'm glad you shared.

    ReplyDelete
    Replies
    1. Thank you
      @
      The disease caused by eating bad meat or the meat from the cattle that infected by a certain disease.

      Delete
  26. Grazie per la visita nel mio blog. Torna presto a trovarmi!

    ReplyDelete
  27. so the photo above are brain tissues after being colored

    ReplyDelete
  28. thank you for great knowledge ,i am enjoying to learn through you my friend

    ReplyDelete
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