Tuesday, July 23, 2019

What are signs of the mutant genes in the Early Onset Familial Alzheimer's Disease? - Alzheimer's #6.

Previously, I posted about chromosomes related to the Alzheimer's disease and gene mutations as the genetic marker that lead to this pathological disease.

As we might know that the progressive declined in cognitive functions in Alzheimer's disease are associated with depositions of aggregated protein in form of extracellular plaques and neurofibrillary tangles in the brain.

Early-onset Alzheimer's disease appears about in the thirties and mid-sixties of the age which are characterized by the mutation of single gene in any chromosome in chromosome 1, chromosome 14, and chromosome 21.

Long investigations about the mutant gene that causes abundance of amyloid plaques were conducted, then the scientists found that this gene, the gene encoding amyloid precursor protein (APP), sits in chromosome 21. It's an autosomal dominant.

The mutant genes in another autosomal dominant forms of Alzheimer's disease were in chromosome 1 and 14.

This mutations lead to abnormal Presenilin 1 and Presenilin 2, which modified amyloid precursor protein so that increase amount of toxic form of Aß peptide.

Presenilins are kind of catalytic protease complexes that directly cleave the amyloid precursor protein.

A person who carrying Presenilin mutation shown an alteration different of variant of amyloid beta peptides in the cerebrospinal fluid.

Mutation of presenil 1 and presenil 2 modify processing of amyloid precursor protein the increasingly of particular toxic form of Aß peptide. This mutation suspects a heritable form of Alzheimer's disease.

So, the signs of mutant genes that lead to early onset Alzheimer's disease is prominent amyloid deposit in the brain. The abnormal process of amyloid precursor protein lead to extracellular deposit. The amyloid deposit is characteristic fibrils of amyloid beta peptide.

Here, my fav lady who always make me smile :)



71 comments:

  1. Que interesante. Yo tengo un familiar con esa enfermedad. Saludos amiga.

    ReplyDelete
    Replies
    1. i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
      or
      call/whatsapp:+2349057261346

      Delete
    2. Just wanna say a big thank you patrice cythia for introducing me to Dr Ezomo the great HERBALIST that helped me prepare home remedies that cured my herpes simplex virus (HSV1&2) I was infected with herpes for the past two years and i was not happy all day so i was desperate to get a cure so that i can live normal and get healthy. One day i was less busy so i decided to make latest research on herpes cure and i found a site were everyone was talking about Dr Ezomo and has ability to cure Herpes, HIV, HPV, Cancer, ALS, COPD, Anthrax, genital wart, cold sore, Arthritis skin tag and all manners of diseases and virus. So i discussed with cythia and she explained to me that its very easy working with Dr Ezomo so i contacted Dr Ezomo via email dr.dr.ezomorootandherbals@gmail.com and he helped me just as he has helped others now I am now cured from herpes am very happy now. and i can also assure you that he can also help you. so if you need the service of DR Ezomo kindly contact him dr.ezomorootandherbals@gmail.com. or whatsapp +2349069171173
      He can also cure so many sickness

      Delete
    3. Sandra.
      Appreciate:
      What are signs of the mutant genes in the Early Onset Familial Alzheimer's Disease? - Alzheimer's #6.
      -
      Previously, I posted about chromosomes related to the Alzheimer's disease and gene mutations as the genetic marker that lead to this pathological disease.

      Delete
  2. Oh dear! The first cartoon, sounds very familiar. Sometimes it happens when I opened the fridge or walk into a room....

    ReplyDelete
    Replies
    1. :)
      -
      Early-onset Alzheimer's disease appears about in the thirties and mid-sixties of the age which are characterized by the mutation of single gene in any chromosome in chromosome 1, chromosome 14, and chromosome 21.

      Delete
  3. Replies
    1. Forgetting is very common :)
      -
      Presenilins are kind of catalytic protease complexes that directly cleave the amyloid precursor protein.

      Delete
  4. Hi Evi oh i am always forgetting what i am doing and saying,thankyou for the information my friend xx

    ReplyDelete
    Replies
    1. Me too. I see my myself in those cartoons :)
      -
      Previously, I posted about chromosomes related to the Alzheimer's disease and gene mutations as the genetic marker that lead to this pathological disease.

      Delete
  5. I often forgetting what i am saying ;-)

    ReplyDelete
    Replies
    1. :)
      -
      Presenilins are kind of catalytic protease complexes that directly cleave the amyloid precursor protein.

      Delete
  6. That is a horrible disease...however the lics made me smile☺

    ReplyDelete
  7. Really interesting post. Thanks for sharing.

    Kisses

    ReplyDelete
  8. very interesting this post, and the picture make me remember very long ago...hehehe

    ReplyDelete
    Replies
    1. Thank you
      -
      Early-onset Alzheimer's disease appears about in the thirties and mid-sixties of the age which are characterized by the mutation of single gene in any chromosome in chromosome 1, chromosome 14, and chromosome 21.

      Delete
  9. Son personas muy ancianas en la playa,el esta ayudando a su pareja a levantarse

    ReplyDelete
  10. Love the funny cartoons
    and I'm hoping not to get Alzheimer's Disease
    when I get old. Thanks for sharing this info.

    Ann
    https://roomsofinspiration.blogspot.com/

    ReplyDelete
  11. Very interesting. I always love those old lady comics.

    ReplyDelete
  12. Dear Evi your post is excellent as ever !

    i adore your knowledgeable series of posts that are really important reminder in this part of age for me
    thank you

    oh this lady looks just like me lol

    ReplyDelete
  13. Great post, Thanks for sharing,
    I'm following you! X.

    ReplyDelete
  14. Found the doodles funny !!! Can I share this on Instagram
    www.stylebasket.in

    ReplyDelete
  15. This series on the cruel pathology of Alzheimer's gets more and more interesting. Great contribution, Evi.

    Big hug.

    ReplyDelete
  16. Estupendo post ! Espero tu opinión en mi último post! Feliz noche! 🌻🌻🌻

    ReplyDelete
  17. Interesting post!!

    https://julesonthemoon.com/

    ReplyDelete
  18. Tienes mucha razón el sol es el verdadero dios

    ReplyDelete
  19. Very interesting facts. Thanks for sharing!

    ReplyDelete
  20. Hello, Evi! I am afraid Alzheimer's disease very much. I do hope the Lord will help me to avoid this illness. I pray.

    ReplyDelete
  21. so scary disease. my former neighbor has got this illness

    ReplyDelete
  22. Es una terrible enfermedad gracias por la información te mando un beso

    ReplyDelete
  23. Greetings and have a nice day :)

    ReplyDelete
  24. Grazie per la visita, torna a trovarmi! Buona giornata a presto!

    ReplyDelete
  25. Interesting information. Thanks for sharing.

    ReplyDelete
  26. Es una enfermedad muy triste. Gracias por la información
    Besos,

    ReplyDelete
  27. Makasih mb infonya.. Bermanfaat sekali. Terus ada cara tidak ya untuk bisa terhindar dari penyakit ini? Atau minimal memperkecil resiko munculnya ?

    ReplyDelete
  28. Very interesting and informative post, dear!
    I didn't know all those things about thi disease, but knowledge is always very important!
    XO
    S
    https://s-fashion-avenue.blogspot.com

    ReplyDelete
  29. Interesting post my dear, thank you for sharing :-)

    ReplyDelete
  30. Serious problems with a touch of humor!!
    xoxo

    marisasclosetblog.com

    ReplyDelete
  31. A helpful post thanks for bringing it to our attention it helps having knowledge of the issue.

    ReplyDelete
  32. Another informative post, Evi!

    ReplyDelete
  33. La imaginación,ese don que nunca debemos olvidar

    ReplyDelete
  34. Alzheimer's disease is so scary because it is so debilitating. Thanks for sharing.

    ReplyDelete
  35. Hello!
    What an interesting post about that hard disease.
    Thank you very much for sharing the information.
    A huge kiss ✿

    ReplyDelete
  36. Bom fds!

    juliamodelodemodelo.blogspot.com

    ReplyDelete
    Replies
    1. Thank you
      -
      As we might know that the progressive declined in cognitive functions in Alzheimer's disease are associated with depositions of aggregated protein in form of extracellular plaques and neurofibrillary tangles in the brain.

      Delete
  37. Very informative. Thanks for sharing.

    ReplyDelete
    Replies
    1. Thank you
      -
      This mutations lead to abnormal Presenilin 1 and Presenilin 2, which modified amyloid precursor protein so that increase amount of toxic form of Aß peptide.

      Delete
  38. Alzheimer is one of the scariest things to me.

    ReplyDelete
  39. 'Amyloyd deposit' in the brain - that's scary!
    Thanks for explaining the matter to us; as they say, 'knowledge is power'

    ReplyDelete
  40. I'm very into this subject. Interesting post :)

    ReplyDelete
  41. Very interesting post- Alzheimer is so tough thing not only for person who is suffer but mostly for the people around - the closest ones

    ReplyDelete
  42. This comment has been removed by the author.

    ReplyDelete
    Replies
    1. Very interesting post and pictures.
      Greetings from Berlin und thanks for your visit :)

      Delete
  43. Thanks for the information, a very sad disease ... 😘😘

    ReplyDelete
  44. Very helpful sharing, thanks a lot .

    ReplyDelete
  45. Interesante post
    ! Gracias por la visita! Feliz noche! 😘😘😘

    ReplyDelete
  46. I'm learning so much from this post. Thanks for the info.

    ReplyDelete
  47. i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
    or
    call/whatsapp:+2349057261346

    ReplyDelete
  48. hahahaha... like Bermuda Triangle?

    ReplyDelete
    Replies
    1. Indeed!
      -
      This mutations lead to abnormal Presenilin 1 and Presenilin 2, which modified amyloid precursor protein so that increase amount of toxic form of Aß peptide.

      Delete
  49. I think it's important for all of us to know about this horrid disease. I suspect we'll see a lot more of it before they can come up with something to either cure or at least hold things off longer than now.

    ReplyDelete
  50. Just wanna say a big thank you patrice cythia for introducing me to Dr Ezomo the great HERBALIST that helped me prepare home remedies that cured my herpes simplex virus (HSV1&2) I was infected with herpes for the past two years and i was not happy all day so i was desperate to get a cure so that i can live normal and get healthy. One day i was less busy so i decided to make latest research on herpes cure and i found a site were everyone was talking about Dr Ezomo and has ability to cure Herpes, HIV, HPV, Cancer, ALS, COPD, Anthrax, genital wart, cold sore, Arthritis skin tag and all manners of diseases and virus. So i discussed with cythia and she explained to me that its very easy working with Dr Ezomo so i contacted Dr Ezomo via email dr.dr.ezomorootandherbals@gmail.com and he helped me just as he has helped others now I am now cured from herpes am very happy now. and i can also assure you that he can also help you. so if you need the service of DR Ezomo kindly contact him dr.ezomorootandherbals@gmail.com. or whatsapp +2349069171173
    He can also cure so many sickness

    ReplyDelete
  51. Mais um post super interessante, e muito completo sobre este tema!
    Gostei imenso!
    Beijinhos
    Ana

    ReplyDelete
  52. i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
    or
    call/whatsapp:+2349057261346




    i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
    or
    call/whatsapp:+2349057261346

    ReplyDelete
  53. I was diagnose with human papilloma virus (HPV) 4 years ago and i met a doctor he told me there is no cure and i have be taking some medication the warts multiplied when trying to removed them and it got me embarrass and pains, luckily few weeks ago i was recommend to Dr bante for natural treatment after one week i got 100% cure and all the wart and pains got disappeared, i sheared this post because its part of my life experience, encase anyone need speedy help about this cure email Dr bante via, bantespelltemple@gmail.com or whatsapp him on +2349063962262. add on hangout bantespelltemple@gmail.com

    ReplyDelete

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