Wednesday, August 7, 2019

What are Factors Causing the Late Onset Alzheimer's Diseases?- Alzheimer’s 07

The cartoon above is an illustration about a relationship of Brain and Heart that I pulled from the awkwardyetidotcom.

In previous posts, several signs of the early onset Alzheimer's dementia had been covered. Now, it is about the late onset, the symptoms appear when a person in the mid 60s and later of age.

The exactly causes of late onset are remaining unknown. The scientists believe the cause could be a combination of three factors:
- life style
- environment
- genetic.

Genetic markers related to the late onset form of Alzheimer's disease is associated with chromosome 19.

The mutation genes that cause increase Apoliprotein E (APOE). A person who inherit one copy of the APOE e4 has a big chance for developing this disease.

APOE primarily produced by liver and macrophages, and APOE4 is associated with hyperlipidaemia and hypercholesterolemia.

Generally, the APOE is associated with various conditions of disease progression, not only Alzheimer's Disease, but also:
- Multiple Sclerosis
- Parkinson's Disease
- Vascular Dementia
- Type 2 Diabetes Melitus
- Ischemia Stroke
- Type III Hyperlipoproteinemia. 


Astrocyte (Neuroscience, Purves et al).
In our brain, APOE is mainly produced by astrocyte

In the late onset Alzheimer's disease, there are three type APOEs:
- APOE2 is associated with reduced risk of Alzheimer's
- APOE3 the most common variant and is considered neutral
- APOE4 is associated with a greater risk.

The function of APOE is to regulate lipid transport from one cell type or tissue to another.

In our brain, APOE is mainly produced by astrocyte and its function is to transport cholesterol to our nerve cell (neuron) in the brain.

Whenever an imbalance between the production and clearance of beta-amyloid peptide in our brain, thus, the accumulation and aggregation of beta-amyloid will be occurred. This become a toxic in our brain.

This toxicity also depend on the paired helical filaments of the microtubuli-associated protein tau.

So, in the late onset Alzheimer's disease, the toxic in the brain destroy the nice balancing of healthy brain, prominently the two proteins which are called beta-amyloid and tau.

64 comments:

  1. Very interesting. Thanks for the information.

    Best regards

    ReplyDelete
    Replies
    1. i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
      or
      call/whatsapp:+2349057261346




      i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
      or
      call/whatsapp:+2349057261346

      Delete
    2. Appreciate..
      What are Factors Causing the Late Onset Alzheimer's Diseases?- Alzheimer’s 07
      -
      The cartoon above is an illustration about a relationship of Brain and Heart that I pulled from the awkwardyetidotcom.

      Delete
    3. Eric> Appreciate:
      What are Factors Causing the Late Onset Alzheimer's Diseases?- Alzheimer’s 07
      -
      In previous posts, several signs of the early onset Alzheimer's dementia had been covered. Now, it is about the late onset, the symptoms appear when a person in the mid 60s and later of age.

      Delete
  2. Replies
    1. Appreciate:
      What are Factors Causing the Late Onset Alzheimer's Diseases?- Alzheimer’s 07
      -
      The exactly causes of late onset are remaining unknown. The scientists believe the cause could be a combination of three factors:
      - life style
      - environment
      - genetic.

      Delete
  3. I wonder if my doctor is willing to check my APOE gene. Thanks for sharing, Evi.

    ReplyDelete
  4. Such great points to consider! Thanks for sharing.

    www.jessicabroyles.com

    ReplyDelete
  5. It is a terrible disease! May our Lord gives all of us good health.

    ReplyDelete
  6. Very good information Thank you!

    ReplyDelete
  7. Those kind of post are always very interesting!
    Full of very important informations!
    Thanx for share!
    XO
    S
    https://s-fashion-avenue.blogspot.com

    ReplyDelete
  8. Great contribution you are getting spread with this series about Alzheimer's, Evi. Humor and not so much. I would say wisdom to be able to express it and make it clear and that it remains even sharper.

    Huge hug!!

    ReplyDelete
  9. Sharper is correct? Means very clear?

    ReplyDelete
  10. Thanks for sharing, it is in my family.

    ReplyDelete
  11. Great post!
    www.somosvisiveiseinfinitos.com.br

    ReplyDelete
  12. Hi Evi what an interesting post ,thankyou for sharing your information with us xx

    ReplyDelete
  13. So great post

    Kisses
    www.pimentadeacucar.com

    ReplyDelete
  14. Gracias por la información. Uno debe cuidarse del Alzheimer como las otras enfermedades Te mando un beso

    ReplyDelete
  15. I think a check of the APOE gene check really would make sense ...
    xx from Bavaria/Germany, Rena
    www.dressedwithsoul.com

    ReplyDelete
  16. Thank you for spreading the awareness about Alzheimer's.

    https://sarahrizaga.blogspot.com/

    ReplyDelete
  17. Thanks for the info, thats a terrible deasese.
    Xoxo

    marisasclosetblog.com

    ReplyDelete
  18. It's a terrible disease. Thanks for the information.

    ReplyDelete
  19. Buena información para los que tenemos una edad avanzada

    ReplyDelete
  20. I must confes i´ve learned a lot about the Alzheimer's thanks to you

    ReplyDelete
  21. Interesante información. Tengo un familiar con esa enfermedad. Saludos y abrazo amiga.

    ReplyDelete
  22. Thanks a lot :D

    very interesting post

    NEW MAN TO MAN POST | MODERN MEN TAKE CARE OF THE HAIR!
    InstagramFacebook Official PageMiguel Gouveia / Blog Pieces Of Me :D

    ReplyDelete
  23. Good to know more about this disease.

    ReplyDelete
  24. Vert interesting! Have a lovely weekend ☺

    ReplyDelete
  25. That cartoon is pretty funny:D And thank you for another informative post about Alzheimer.

    ReplyDelete
  26. Mudah2an nanti aku udah tuanya gak alzheimer. Waktu itu pernah nonton film apa ya lupa... tentang alzheimer itu. Aku jadi ngeri :(

    ReplyDelete
  27. gracias por la información.
    Un beso! ;)

    ReplyDelete
  28. Ótimo post!
    bjs
    http://www.pinkbelezura.com/

    ReplyDelete
  29. Celebo te sigan gustando mis fotos.

    Saludos desde Andalucia

    ReplyDelete
  30. (。◕ ‿ ◕。)/ Holaaa!!!
    Justamente el otro día vi en la televisión que estaban haciendo estudios para detectar esta enfermedad desde la juventud, si fuera así se supone que encontrarían una posible solución. Gracias por la información :D

    Te invito a visitar mi humilde espacio ♥

    穛 S4Ku SEK4i®

    ReplyDelete
  31. interesting information
    I've always wondered where Alzheimer comes from?
    greetings
    Lili

    ReplyDelete
  32. Absolutely delicious =)

    Very interesting, thanks for the information.

    ReplyDelete
  33. So if someone has already got a specific disease written above, and his father or mother passed away caused by alzheimer's, he is vulnerable to inherit this illness?

    ReplyDelete
  34. that's a terrible disease hope they find a cure.
    xoxo

    marisasclosetblog.com

    ReplyDelete
  35. Creo que se está avanzando mucho la investigación sobre la enfermedad y que se están probando nuevos fármacos para combatirla.

    Besos

    ReplyDelete
  36. Alzheimer's is really scary and debilitating. Thanks for sharing.

    ReplyDelete
  37. Gracias por este artículo Evi. Me ha parecido muy interesante. Muchísimas gracias, el alzheimer es una enfermedad muy, muy importante.
    Besos :D

    ReplyDelete
  38. To bardzo skomplikowane, mam nadzieję że mnie ominie ta okropna choroba. Serdeczności Evi.

    ReplyDelete
  39. Thanks for sharing, it was interesting post.

    ReplyDelete
  40. Very interesting information, thank you!
    xx

    ReplyDelete
  41. These posts are really interesting and I've been bookmarking them, hoping I won't ever need to refer to them, yet knowing it's always a possibility.

    ReplyDelete
  42. Um post muito útil! Confesso que já estava a par de alguma desta informação, pois é um tema pelo qual me interesso, até porque tenho uma pessoa amiga, que há alguns anos atrás foi diagnosticada com esta doença!...
    Beijinho
    Ana

    ReplyDelete
  43. i believe, life style and environment contribute more not only for Alzheimer but also for other diseases

    ReplyDelete
  44. Thanks for sharing, it was interesting post.Kisses

    ReplyDelete
  45. i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
    or
    call/whatsapp:+2349057261346




    i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
    or
    call/whatsapp:+2349057261346

    ReplyDelete

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